Amiodarone: Single dose: 58 days (range: 15 to 142 days) Oral chronic therapy: Mean range: 40 to 55 days (range: 26 to 107 days) IV single dose: Mean range: 9 to 36 days. Digoxin loading oral: 500-750mcg 2 doses 6 hours apart (max 1500mcg in 24 hours) Maintenance dose. Start at 400 mg PO BID, until the patient has received a total of 10 grams cumulative dose (both IV and PO). Adjust to the lowest possible dose to limit side effects. Note: This is for converting oral opioids only, and should not be used for IV to oral conversions. VF and pulseless VT: 300 mg IV/IO push. Critical Care Intravenous Flow Rates Example 1: The order is to infuse nitroglycerin at 5 mcg/min; 50 mg of Study Resources A client is receiving an IV solution of sodium chloride 0.9% (Normal Saline) 250 ml with amiodarone (Cordarone) 1 gram at 17 ml/hour. 2. The initial infusion rate is not greater than 30 mg/min. 3. This should be administered as a dilute solution in 250ml 5% w/v dextrose. Calculate new dose using ratios: 180/30 X 7.5 = 45 mg oral Hydromorphone/24 hours. 2, 10 In patients who require long-term treatment, intravenous dosing should be switched to oral dosing. Suggested Pediatric Drug Dosages 07/05/2005 Zwi Jacob, MD Download 2 page pdf version for printing The dosages and drugs are intended as general guidelines ONLY. Determine the new opioid analgesic to convert to and using equianalgesic dosing data (taking into consideration the limitations) convert to new opioid dose. Amiodarone may take 2 weeks or longer to have an effect in your body. 1 yr. ago. Loop diuretic PO --> IV conversions Furosemide 40 mg PO = Furosemide 20 mg IV = Torsemide 20 mg PO/IV = Bumetanide 1 mg PO/IV #Pharmacology #Cardiology #Loop #Diuretics #Equivalent #Dose #Conversion #Table #Furosemide #Torsemide #Bumex #Lasix #Bumetanide ** GrepMed Recommended Text: Clinical Pharmacology Made … May repeat every 10 minutes PRN. Equivalents are based on 30 mg morphine PO = 10 mg morphine IV = 100 mcg fentanyl IV = 30 mg HYDROcodone PO = 1.5 mg HYDROmorphone IV = 7.5 mg HYDROmorphone PO = 20 mg OXYcodone PO = 1 mg OXYmorphone IV = 10 mg OXYmorphone PO Looking for a more detailed calculator? Amiodarone Intravenous should only be used in a special care unit under continuous monitoring (ECG and blood pressure). The actual drugs and their doses should be administered only following discussion with the attending. New! IV fluids help if patient is dehydrated which can cause AFib. HOW SUPPLIED -----Amiodarone Hydrochloride Injection, 50 mg/mL is supplied in: 3 mL (150 mg) 10 Single-dose vials per carton (NDC 60505-0722-0). IV: 0.05–0.10 mg/kg given over 2–3 min (maximum single dose: 5 mg). Amiodarone was discontinued and IV sotalol was initiated at 42 mg/m2/day, divided to 3 doses, and administered every 8 h, which completely suppressed the arrhythmia. The dosing schedule of amiodarone, with intravenous loading protocols, may mean that the automated intravenous to oral conversion prompt does not provide physicians with the dose recommendations they need for this drug. IV Esmolol infusion is fairly well supported by evidence. All microdrip tubing delivers 60 gtt/mL and is used to deliver a small or very precise amount of fluid. Use the equianalgesic ratio: 30 mg PO Morphine = 7.5 mg PO Hydromorphone. Guardrail Drug Requires documentation of two (2) RN’s for double-checking. Alternative regimen of amiodarone: 600 mg/day for 7 days prior to surgery, followed by 200 mg/day until hospital discharge, has also been shown to decrease the risk of postoperative atrial fibrillation. 1) IV metoprolol has immediate action, PO has slow and graded release over hours. some source region to absorbed dose in a target region…”. Try the most comprehensive online opioid calculator available! With intravenous use: Avoid rapid intravenous administration (risk of hypertension and reduced coronary flow). Description. • Then i-Vents acuity will now have a 10 to signify there is a open i-Vent. This will change the medication concentration. DOSAGE. Detailed Amiodarone dosage information for adults. For example, patients are frequently prescribed intravenous glucose 5%. Lidocaine. Calculate total daily oral dose 2. Give VERY RAPID IVP over 1-3 sec. INSTRUCTIONS. However, patients in the metoral group (M) were given a dose of 1–3 mg/kg/h for 24 h. For each group, antiarrhythmia medicines were prescribed for 24 h. IV regimen: Bolus 0.15 mg/kg IV over 10 minutes, then 3-5 mg IV Q6hr. (anephric: 4-6 days). The drip has been infusing for almost 24 hours and the patient had not yet converted. The following pharmacist will check on these open i-Vents and close then when appropriate. An infusion is to run for 30 minutes and is to deliver 200 mL. Methods. is a mathematical representation of the human body used to calculate. A dose of one 200-mg tablet (20 mg/kg q24h) was given to 6 dogs Eventually transition to another agent. How many mg/minute of amiodarone is infusing? Time to steady state: 5-7 days (average) ESRD: 15-20 days. Mr Smith is to receive 800 mL of an antibiotic via an IV infusion over 15 hours. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you're unable to convert to PO before 24 hours, consider decreasing the IV dose to 0.25 mg/min. Chronic use of amiodarone causes a host of side effects. 1. Next. Note: Half-life is shortened in children vs adults. In adult patients, amiodarone can be given for VT/VF cardiac arrest via intravenous (IV)/intraosseous (IO) infusion as a 300 mg rapid bolus followed by an additional bolus of 150 mg IV/IO if VT or VF persists. You can discover more on this subject, check an example calculation and the half times of most known active substances below the form. Automatic IV to PO Conversion Protocol Purpose: To allow for the conversion of intravenous medications to oral equivalents when medically appropriate in an effort to reduce line-associated risk, reduce nosocomial-acquired infection risk, improve patient satisfaction, promotes earlier and easier ambulation, and reduce The physician orders Zantac elixir 150 mg po twice a day for heartburn. Cumulative dose. The standard recommended dose is 5mg/kg bodyweight given by intravenous infusion over a period of 20 minutes to 2 hours. This updated dose conversion is based on recent literature which has shown that the bioavailability of levothyroxine is estimated to be around 79-81 percent. Then you'd transition to a maintenance dose of 100 - 200 mg daily. Calculate the Cp if a 70 yo, 70 kg man with a serum creatinine of 3.0 is given a 1 mg IV loading dose of digoxin. Serious side effects may include lung or liver problems. Dose titration every 3 days monitored or 7 days in chronic use. Infusion Pump Required. #23. 250 mcg twice daily. 3. Onset/peak: IV: 5-30min/ 1-4hrs Oral: 1-2hrs/ 2-8 hrs. Oral maintenance dose. To prepare Amiodarone for an IV infusion, mix with D5W and give through an in-line filter. Calculate the number of units required to deliver the initial bolus dose. Steroid Conversion Calculator. 26 - 107 days. 4. Ketorolac (Toradol®) Early switch over from IV to oral therapy has the following major advantages: Reduced risk of cannula-related infections: For the administration of IV medications, one is required to insert a cannula, which remains in place for some days and eventually can result in secondary infections caused by bacteria and fungi. Dose: 150 mg IV x1 over 10min, then 1 mg/min IV x6h, then 0.5 mg/min IV x18h [PO route] Dose: 400 mg PO qd; Start: load 800-1600 mg PO qd x1-3wk until response, then 400-600 mg PO qd x4wk; Info: divide loading doses >1000 mg/day bid-tid w/ meals; divide maint. Calculate the oral loading dose for a 70 yo, 70 kg adult male with a serum creatinine of 3.0, if the desired Cp is 1.0 ng/ml. VT with pulse (stable) and SVT: 150 mg IV/IO in 50 ml D5W/NS over 10 minutes. Pharmacist –initiated IV to PO conversion program of antimicrobials. [onset time < 20min] EP or general cardiology consult should be requested if long-term amiodarone use is contemplated. <2400mg. IV infusion is preferred to bolus due to the haemodynamic effects sometimes associated with rapid injection (see section 4.8). IV/PO: 4-8 hrs initially; increases to 22-48 hrs with repeated doses. Amiodarone increases PO digoxin serum concentrations by ~70% and IV digoxin by ~17%; measure digoxin levels before initiating amiodarone and reduce PO digoxin dose by 30-50%; decrease IV digoxin dose by 15-30% amiodarone will increase the level or effect of digoxin by basic (cationic) drug competition for renal tubular clearance. (Enter numeric value only. PO. Calculate the total daily opioid dosage (long acting and break through) and convert to morphine equivalents (either IV or PO) using an equianalgesic dosing table. Upon if 5 mg/325 mg, enter "5"). Amiodarone HCl 30 mg IV J0282 Amitriptyline HCl up to 20 mg IM J1320 Amobarbital up to 125 mg IM, IV J0300 Amphocin, see Amphotericin B Amphotericin B 50 mg IV J0285 Amphotericin B, lipid complex 10 mg IV J0287-J0289 … ... Amiodarone. Loading dose. 12. For oral dosage form (tablets): For ventricular arrhythmias: Adults—At first, 800 to 1600 milligrams (mg) per day taken in divided doses. 11. 200mg tds. How to load digoxin. Articles describing intravenous to oral conversion protocols for any therapeutic category were identified in an English-language MEDLINE search (1990-April 2010) using a … Cumulative dose, X = (total IV dose * 2) - (days of treatment * 200); This is then used to determine the appropriate loading dose: -. This medicine half life calculator estimates the action of any medicine and the way concentration decreases in percentage in plasma according to half life and dosage. received, X. The physician orders amiodarone IV drip at 0.5 mg/min for ventricular dysrhythmias. (10942741, 25745472, 32345562) Oral regimen: Propranolol 40 mg PO q6hrs has been proven superior to metoprolol (50 mg q6hr). Steps to covert from diltiazem IV to PO 1. Infuse 150 mg over 10 minutes (15 mg/min). Reduce dose 50% for cross-tolerance: 45 x 0.5 = 22 mg/24 hours = 4 mg q4h. It exhibits all four of the classic Vaughan Williams mechanisms of action, namely sodium and potassium channel blockade, a mild antisympathetic action and some calcium channel blockade, but it is usually classified as a Class III antiarrhythmic drug (see Table 1).It prolongs the … 15mg q6hr, even if equivalent, is hitting them with a whopping dose upfront. Amiodarone [SVT with pulses] 150mg Rapid infusion over 10 minutes 15mg/minute, may repeat q10 minutes as needed Stable in D5W, NS Incompatible with heparin Maximum cumulative dose 2.2g over 24 hours Ativan (lorazepam) 0.1mg/kg Max dose 4mg Dilute 1:1 with NS Max rate 2mg/minute Stable in D5W, LR, NS Monitor IV site avoid extravasation the Dose Factors (DFs) that we need to convert disintegrations in. Intravenous to Oral Conversion for Antimicrobials 1-20-6-1-010 Author(s): Antimicrobial Stewardship Program Coordinator Page 6 of 6 Issuing Authority: Vice President Medicine and Clinical Programs; Regional Director, Pharmacy Services As you can imagine, many of the patients cant take PO, pick your variety of reasons: SBO, Postoperative Ileus, Sigmoid Cancer, blah blah blah. IV Infusion Concen- tration Usual Dosing and Administration Comments Amiodarone X (Cordarone®) exceeding c X Bolus in ode only No infusion X Bolus diluted to 1.5 -3 mg/mLin D5W Infusion 450 mg/ 250 mL in D5W BOLUS: PALS for pulseless VF/VT5 mg/kg (MAX 300 mg/dose) given over 5 10 minutes. 125 mcg twice daily. The medication is supplied in 1 g/250 mL of D 5 W. Calculate the flow … Amiodarone is an iodinated benzofuran derivative that was synthesized and tested as an antianginal agent in the 1960s but was later discovered to have antiarrhythmic properties. Includes dosages for Arrhythmias; plus renal, liver and dialysis adjustments. Monitor BUN and serum creatinine q2days (qd if unstable). 125 mcg twice daily. Oral Amiodarone • Amiodarone has a very long half life so requires a loading regime of 200mg tds for one week, bd for 2nd week then 200mg od • When a change in dose is part of a standard initiation regime, further details on the chart can ensure the change is automatically implemented and prevents missing the review date. Prepare solution with 150 mg amiodarone in 100-mL D5W bag. When infusions exceed 2 hours, amiodarone can absorb into the plastic used for standard IV bags. Click to see full answer. Amiodarone is widely prescribed, largely due to its efficacy in the management of both supraventricular and ventricular arrhythmias. Peak levels after 150 mg of supplemental infusions in patients with VT/VF range between 7 and 26 mg/L. Where volume is the amount of fluid in the IV bag, time is total number of minutes the fluid is to infuse over, and the drop factor (or drip factor) is related to the size of the IV tubing you are using; the number of drops per mL delivered for a particular drip chamber. Patient had also received 3 doses of PO Amio in addition to the drip in the 24 hours. Only $199. Percocet = acetaminophen + oxyCODONE), enter only the dose of the opioid component (e.g. Amiodarone shows considerable interindividual variation in response. IV/PO: 4-8 hrs initially; increases to 22-48 hrs with repeated doses. Amiodarone IV bolus at 150mg over 1 minute, then 1mg/min for 6hours and then 0.5mg/min for 18hours. Considerations for IV-to-PO Conversions. For intravenous infusion ( Lanoxin ®), give intermittently in Glucose 5% or Sodium chloride 0.9%; dilute to a concentration of not more than … The patient was also started on PO amiodorone 400mg BID. RxAdvanced: Guide to Cannabis training for pharmacists that offers 16 hours of ACPE-accredited training based on the latest, science-based cannabis research. Intravenous amiodarone has interesting and complex pharmacokinetics. Can be used to convert between corticosteroid medication dosages for oral and IV administration. Note: Pharmacy sent the bolus in a separate 100 ml bag and the continuous drip in a 500 ml bag. Digoxin Second line rate control agent, primarily because it tends to exert its rate controlling effect at rest, This means that each 100ml of water in … 154/ 2.2 = 70 kg 70 x 80 = 5,600. 1) 5) 1) 5) Step 6. You're typically looking at 400–600 mg daily in divided doses for 2–4 weeks. Thus, although a starting dose adequate to suppress life-threatening arrhythmias is needed, close monitoring with adjustment of dose as needed is essential.The recommended starting dose of Cordarone I.V. Digoxin loading dose IV: 500mcg; followed by 250mcg 6 hours later and a further 250mcg 6 hours after that. Continuous infusion: Bolus 150 mg over 10 min, then start drip. Dexamethasone 0.6 mg/kg IV/IO/ IM/PO Maximum daily dose 16 mg Methylprednisolone sodium succinate 1–2 mg/kg IV/IO/IM Maximum single dose 60 mg ... Do not give with amiodarone Sodium Bicarbonate 1 mEq/kg IV/IO Give as a slow bolus Use 4.2% concentration in infants less than 1 month of age Seizures Drug Dose Comment IV Push for Hyperkalemia. (25033747, 10942741) Loading dose is 0.3-0.5 mg/kg IV (~30 mg). • Also remove sticky note when IV to po is addressed. is about 1000 mg over the first 24 hours of … N-desethylamiodarone (active metabolite): Prolonged in severe left ventricular dysfunction. 62.5mcg – 250mcg daily. IV. Half-Life Elimination. The medication is supplied in 900 mg/500 mL of D 5 W. Calculate the flow rate in milliliters per hour.. 2) The physician orders a lidocaine IV drip to infuse at 3 mg/min for premature ventricular contractions. Maintenance = (Cl) (Cp) (t) Dose (F) Cp = (F) (dose/ t) Cl Cl equations for digoxin If the patient is taking 0.5 mg IV then the PO dose would be 0.5 mg multiplied by 5, which is 2.5 mg. For combination drugs (e.g. What is the rate of the infusion in mL/h? Amiodarone is an antiarrhythmic drug with structural similarities to thyroxine. Drug Usual IV Dose* Approximate PO Dose* PO to IV Considerations/Comments Reference digoxin 0.1 -0.4 mg IV Q 24 H 0.125 -0.5 mg PO Q 24 H Oral bioavailability about 80% for tablets and liquid 1,2 dimenhyDRINATE 25-50 mg IV 25-50 mg PO Conversion of … Restated: Duration of IV infusion < 1 week: 800-1600mg/day po initially x 1-2 weeks or complete current week; 1-3 weeks: 600-800mg/day po initially - total therapy ~ 1 month counting IV infusion ; >3 weeks: 400mg po qd initially. IV/IM: 1–2 mg/kg initial dose (must use acetate salt for IM route). The objective of this study was to assess the impact of IV and PO amiodarone overlap on short-term tachyarrhythmia recurrence and adverse hemodynamic outcomes in the intensive care unit. 3 Based on this data, the ATA Guidelines and Lexicomp recommend administering an IV dose that is 75 percent of the oral dose when converting from a parenteral to enteral route. IV infusion IV Infusion IV Infusion (OB) Only REGULAR insulin may be administered by the IV route. Negative inotropy is an adverse feature of most antiarrhythmic drugs. The plasma half-life of amiodarone after single-dose administration has been reported to be in the range of 3.2 to 79.7 hours. Calculate the 24 hour current dose: 90 Q12 x 2 = 180 mg PO Morphine/24 hrs. Loop diuretic PO --> IV conversions Furosemide 40 mg PO = Furosemide 20 mg IV = Torsemide 20 mg PO/IV = Bumetanide 1 mg PO/IV #Pharmacology #Cardiology #Loop #Diuretics #Equivalent #Dose #Conversion #Table #Furosemide #Torsemide #Bumex #Lasix #Bumetanide ** GrepMed Recommended Text: Clinical Pharmacology Made … The patient was in Afib and the MD ordered a bolus of Ami followed by a continious drip. In the text below the tool you can find out more about the substances that are available to be converted. Description. 15 mg/hr to 480 mg/day. 12 mg IV x1 dose. • After completion of a risk/benefit analysis, the QAS authorises the administration of sodium chloride 0.9% (flush or running IV line) following amiodarone administration in cardiac arrest, despite manufacturer’s recommendations. 2) Despite a reported duration of 5-8 hours, the peak/effective duration for IV is 30-60 minutes at best. I've seen an IV Amio bolus drop pressures, but that's typically when it's given over 15 minutes. Calculate the flow rate to be set. A patient started on oral (PO) amiodarone approximately 1 week ago (400 mg/day). However, after withdrawal of long term amiodarone treatment the half-life is as long as 100 days. 0.22 micron filter preferred . A percentage means ‘out of 100’, so a percentage concentration can be defined as the amount of drug in 100 parts of the product. Drugs; Diseases; Interaction Check; Pill ID; ... Dosing Calculator; Peds Dosing . 2. Faebinder said: Our floor policy (as in the floor where I admit 90% of my patients) frigging wont give lopressor IV even if the person was on lopressor PO prior to admission. Drug Usual IV Dose* Approximate PO Dose* PO to IV Considerations/Comments Reference digoxin 0.1 -0.4 mg IV Q 24 H 0.125 -0.5 mg PO Q 24 H Oral bioavailability about 80% for tablets and liquid 1,2 dimenhyDRINATE 25-50 mg IV 25-50 mg PO Conversion of … Subsequently, the dose may be decreased to 200 mg daily. Typical amiodarone dosages in the ACLS setting are provided in Table 1. The pharmacist leaving the sticky not will open and IV to po i-Vent, leave this i-Vent open until the medication is changed. Also, this drug stays in your body for weeks to months, even after you are no longer taking it. Common IV to PO Drug Conversions 1) Metoprolol 1:2.5 2) Diltiazem Oral Dose (mg/day) = [ rate (mg/hr) x 3 + 3 ] x 10 3) Digoxin 0.75:1 4) Levothyroxine 0.75:1 5) Aminophylline to Theophylline 1:0.8 6) Ciprofloxacin 1:1.25 #IVtoPO #Drug #Conversion #Pharmacology #Common #Intravenous #Oral. received via the IV route, as follows: -. Calculate the flow rate if 1.2 L is to be infused over 24 hours. Warfarin 3. Monitor apical pulse daily. Posology. The objective of this study was to assess the impact of IV and PO amiodarone overlap on short-term tachyarrhythmia recurrence and adverse hemodynamic outcomes in the intensive care unit. This has to do with the very high volume of distribution (part of why you give the 150mg load). Flush post dose. Oral. If rounding is required, round to the nearest tenth.) followed by 20 ml saline flush Amiodarone 50 mg/ml vial Pulseless VT or VF: 300 mg IVP. For continuous infusions, conc. Half-life: 38-48 hrs. Atrial Fib 150 mg IV/IO in 50 ml D5W/NS over 10 minutes. After IVP, Flush with 20 ml of D5W or NS. Give first PO dose 1 hour prior to ... Amiodarone PO dosing in hospital After converts to NSR or after 24 hrs, 400mg PO BID up to 10g load (includes IV), then 200mg daily. Oct 27, 2007. This number means that the PO dose is 5 times more than the IV dose to get the same amount of drug into the bloodstream. Flush with 20 ml of D5W/NS. Alternatively, it is NOT necessary to dilute amiodarone for IV push administration and a filter is not necessary. For amiodarone, more than 20% of orders were canceled, but none were directly converted to the oral route. Amiodarone increases PO digoxin serum concentrations by ~70% and IV digoxin by ~17%; measure digoxin levels before initiating amiodarone and reduce PO digoxin dose by 30-50%; decrease IV digoxin dose by 15-30% amiodarone will increase the level or effect of digoxin by basic (cationic) drug competition for renal tubular clearance. Oral loading dose. Dose titration every 3 days monitored or 7 days in chronic use. 1)The physician orders amiodarone IV drip at 0.5 mg/min for ventricular dysrhythmias. Loading dose: 800–1,600 mg/day PO in divided doses, for 1–3 wk; reduce dose to 600–800 mg/day in divided doses for 1 mo; if rhythm is stable, reduce dose to 400 mg/day in one to two divided doses for maintenance dose. From what I've been taught IV Amio has immediate effect, while PO Amio takes days/weeks to kick in. Patients in the amiodarone group were given a STAT dose of 300 mg of amiodarone (A) followed by a dose of 1–3 mg/kg for every 6 h and 0.5 mg/kg 18 h later. IV. Follow with a slow infusion of 360 mg over the next 6 hours (1 mg/min). 5. This calculator is not appropriate for the following patient populations: Significant drug interactions (eg, amiodarone, quinidine, verapamil, or macrolide antibiotics) End-stage renal disease on hemodialysis; Acute renal failure or unstable renal function; The following bioavailabilities (F) are used for calculation: Tablet = 0.75; Intravenous = 1 What is the simpliest method to calculate this into ml/hr. The total daily dose should be divided q6h. IV loading should only be performed when a rapid response is required. No further down titration of Tikosyn based on QTc or QT is recommended. At 2–3 hours after each subsequent dose of Tikosyn, determine the QTc or QT (if heart rate is less than 60 beats per minute) (for in-hospital doses 2–5). Follow up with an infusion of 1 mg/min IV x 6 hours, then 0.5 mg/min IV x 18 hours. Amiodarone Mechanism : Amiodarone is a class three anti-arrhythmic drug. EKG. Cardizem 5-20mg iv bolus [or Metoprolol 5mg IV], a repeat dose may be needed in 15min and if not converted to sinus–>Cardizem iv drip starting with 5mg/hr [or Amiodarone bolus f/b drip if BP is low.] IV: 150 mg IV over 10 minutes. doses bid w/ meals if GI intolerance View Critical Care Intravenous Flow Rates Quiz.docx from MATH 335 at El Dorado High School. Round dose to a 30 mg increment, divide this daily dose by 4 to give Q6H dosing 3. Store at 20° to 25°C (68° to 77°F) Protect from light. IV: 30 mg/kg over 15 min, followed in 45 min by a continuous infusion of 5.4 mg/kg per h for 23 h. Administration within 8 h of injury is optimal. amiodarone pediatric dosing. 3. If the patient achieves ROSC, a continuous infusion is started at 1 mg/min for 6 hours, followed by 0.5 mg/min. QT interval from excess amiodarone administration, magnesium sulphate administration is to be considered. Indication : Refractory supraventricular tachycardia; Junctional ectopic tachycardia; Atrial fibrillation Dogs were given amiodarone at 8:00 AM and 8:00 PM daily for the loading dose and at 8:00 AM daily for the maintenance. Description. VT with pulse unstable: 1st dose 150mg IVP/IOP under 2 minutes - 2nd dose 150mg IV/IO in 50ml D5W/NS over 10 min. Stable VT: 150 mg IV over 10 min May repeat with 150 mg IVP if needed. Medline ® Abstract for Reference {{configCtrl2.info.canonicalUrl}} of 'Amiodarone: Clinical uses' Peak serum concentrations after 15-minute infusions in healthy volunteers range from 5 to 41 mg/L. Asymptomatic blue-grey discolouration of exposed areas can also occur. Amiodarone should only be used when facilities exist for cardiac monitoring, defibrillation, and cardiac pacing. Although amiodarone exerts its antiarrhythmic effect by an interplay of different actions on cardiac cells, it has been regarded to be the prototype class III drug due to its prolongation of action potential duration. DOSAGE AND ADMINISTRATION. 290.914.916.010. Prepare solution with 900 mg amiodarone in 500 mL D5W glass bottle. To determine the dose conversion IV to PO, the ratio of PO to IV needs to be determined, this is 7.5 / 1.5 which is 5. If intravenous amiodarone is administered during pregnancy, the patient should be apprised of the potential hazard to the fetus. In practice, steroids may have to be administered alternatively or substituted for oral and IV administration. The initial sotalol dose was calculated based on a daily dose of 90 mg/m2 and reduced by an age-related factor as recommended by the FDA approved prescribing information. 100 unit / 100 ml (1 unit/ml). 5. including oral and intravenous regimens: -Oral: Starting in postop recovery, 400 mg twice daily for up to 7 days. It works in two ways (1) prolongation of the myocardial cell-action potential duration and refractory period and (2) non-competitive alpha- and beta-adrenergic inhibition. RADAR Phantoms Calculator INPUT Values include: Phantom “…Adult Male & Male; 15, 10, 5, 1 Year Old; Newborn; etc…”. No matter which strategy you follow with amiodarone, the goal is to transition to PO within 24 hours. Intravenous administration Extravasation of amiodarone can cause significant tissue damage including necrosis. an oscillometric method.c Amiodaroned was administered, 200 mg/dog, PO q12h for 3.5 weeks, and then 200 mg/dog PO q24h for 3.5 addi-tional weeks. PO amiodarone 25.7 mg/kg vs. IV amiodarone 3‐5 mg/kg bolus then 10‐15 mg/kg over 24 h No difference in conversion to SR between PO and IV (64% vs. 68%, respectively; p=NS) 223 patients with symptomatic atrial fibrillation on digoxin PO amiodarone 600 mg in3 divided doses vs. IV amiodarone 5mg/kg over